Research Articles
Dopamine Challenge Studies: A Comprehensive Guide to Pharmacological Probing of Human Reward Pathways for Research & Drug Development
This comprehensive review explores pharmacological challenge studies as a critical tool for investigating dopamine-mediated reward functioning in humans.
PSA-NCAM: The Dynamic Neuroplasticity Marker in Brain Function, Disease, and Therapeutic Development
Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) is a pivotal, developmentally regulated marker of structural and functional neuroplasticity.
PSA-NCAM as a Neuroregeneration Biomarker: Validation Strategies, Cross-Species Challenges, and Therapeutic Implications
This article provides a comprehensive review for researchers and drug development professionals on the validation of Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) as a critical biomarker for neuroregeneration.
PET vs MRI for Neural Circuit Mapping: A Comprehensive Guide for Researchers in Neuroscience and Drug Development
This article provides a detailed comparative analysis of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) for mapping neural circuits, tailored for researchers, scientists, and drug development professionals.
Clearing the Path to Discovery: A Comprehensive Guide to PACT and PARS Tissue Clearing for 3D Imaging
This article provides a complete resource on Passive Clarity Technique (PACT) and its derivative, Perfusion-Assisted Agent Release in Situ (PARS), two hydrogel-based tissue clearing methodologies revolutionizing 3D imaging in biomedical...
Bridging the Translational Gap: Challenges and Solutions in Applying Animal Dopamine Research to Human Neuropsychiatry
This article examines the critical translational challenges in extrapolating dopamine findings from animal models to human neuropsychiatric research and drug development.
Dopamine Receptor Challenge Design: Strategies for Disentangling D1 vs. D2 Receptor Pharmacology in Human and Preclinical Studies
This article provides a comprehensive methodological framework for designing and optimizing pharmacological challenge paradigms to dissect the distinct contributions of dopamine D1 and D2 receptor systems.
Strategies for Optimizing Dopamine Antagonist Dosing: Minimizing EPS, Akathisia, and Tardive Dyskinesia in Clinical Practice and Drug Development
This article provides a comprehensive analysis of contemporary strategies for optimizing doses of dopamine receptor antagonists (DRAs) to minimize motor side effects, including extrapyramidal symptoms (EPS), akathisia, and tardive dyskinesia.
Beyond Reward: How Dopamine Shapes Cognitive Motivation and Drives Goal-Directed Behavior
This article provides a comprehensive synthesis for researchers and drug development professionals on dopamine's neuromodulatory role in the cognitive facets of motivation.
In Vivo Dopamine Dynamics: Decoding Phasic vs. Tonic Release Signals for Neuropharmacology
This article provides a comprehensive guide for neuroscience researchers and drug development professionals on the critical methods for distinguishing between phasic (brief, burst-like) and tonic (sustained, baseline) dopamine release in...